CP-654577

Overview

CP-654577 is a selective ErbB2 inhibitor with an IC 50 of 11 nM. CP-654577 downregulates the Notch1 signaling pathway. CP-654577 upregulates p27 kip1 , reduces the levels of Cyclins D and E, and inhibits G1 phase progression of the cell cycle. CP-654577 induces cell Apoptosis , downregulates activated Akt , and suppresses tumor growth in athymic mice. CP-654577 can be used in breast cancer-related research.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Notch | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Akt | Products > Signaling Pathways > EGFR

Product Information

• Catalog No.: HY-118900
• CAS No.: 639087-64-2
• Molecular Formula: C34H32N4O3
• Molecular Weight: 544.66
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source