IM-12 (GMP)

Overview

IM-12 GMP is IM-12 ( HY-12292 ) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. IM-12 is an orally active anti-inflammatory agent that targets and inhibits the NF-κB and STAT3 signaling pathways. IM-12 activates the Wnt signaling pathway and promotes the nuclear translocation of β-catenin by inhibiting GSK3β , while also blocking the tyrosine kinase activity of p210BCR/ABL . IM-12 reduces the levels of IL-6 , IL-17 , NO , prostaglandin E2 , iNOS and COX-2 , and induces ER stress, Ca 2+ release, autophagy and apoptosis . IM-12 is heat-sensitive and does not induce autophagy in IM-resistant p210BCR/ABL T315I mutant cells. IM-12 is also a component of the 5iLA medium used for naive pluripotent stem cell research. IM-12 has been applied in studies related to carrageenan ( HY-125474 )-induced hind paw edema, TNBS-induced colitis, and acute and chronic myeloid leukemia.

Application

Products | Products > GMP Small Molecules | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > β-catenin | Products > Signaling Pathways > Bcr-Abl | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > STAT | Products > Signaling Pathways > GSK-3

Product Information

• Catalog No.: HY-12292G
• CAS No.: 1129669-05-1
• Molecular Formula: C22H20FN3O2
• Molecular Weight: 377.41
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source