DKFZ-633 is a potent KLK6 inhibitor and KLK6 -specific probe with an IC 50 of 250 nM against human KLK6 . DKFZ-633 covalently labels active KLK6 in a specific manner, and successfully pulls down and captures endogenous active KLK6 from cell-conditioned media. DKFZ-633 serves as a critical tool for investigating the function of KLK6 and its regulatory mechanisms in head and neck cancer .
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