DKFZ-251

Overview

DKFZ-251 is a kininogenase-related peptidase KLK6 inhibitor ( IC 50 =0.47 μM), and also exhibits certain inhibitory activity against KLK5 and KLK7 ( IC 50 values are 1.1 nM and 73 nM, respectively). DKFZ-251 transiently acylates the catalytic serine of KLK6 to form a long-lived acyl-enzyme complex that inhibits enzyme function. DKFZ-251 is a phenotypic modulator that alters cell proliferation capacity and regulates epithelial-mesenchymal transition (EMT). DKFZ-251 can be used in research related to head and neck cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > Kallikrein

Product Information

• Catalog No.: HY-124714
• CAS No.: 2222059-70-1
• Molecular Formula: C24H24N4O3
• Molecular Weight: 416.48
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source