TH251

Overview

TH251 is a LIMK1 and LIMK2 inhibitor with IC 50 s of 52 nM and 47 nM against LIMK1 and LIMK2 , respectively. TH251 binds to inactive αC-out and DFG-out LIMK1 conformations, inhibits unphosphorylated LIMK1 and LIMK2 enzymatic activity, and exhibits unchanged potency despite PAK-mediated phosphorylation of either kinase. TH251 can be used for the research of cancers, glaucoma, and CNS diseases.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Visual System Disease | Products > Disease Areas > Glaucoma | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Neurological Disease | Products > Research Areas > Cancer | Products > Signaling Pathways > LIM Kinase (LIMK)

Product Information

• Catalog No.: HY-125444
• CAS No.: 1622059-04-4
• Molecular Formula: C22H22N2O3S
• Molecular Weight: 394.49
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source