IWP-4 (GMP)

Overview

IWP-4 (GMP) is the GMP-grade form of IWP-4 ( HY-12879 ). IWP-4 is a Wnt inhibitor with an IC 50 of 25 nM. IWP-4 specifically inhibits casein kinase 1δ/ε ( CK1δ/ε ), with an IC 50 of 1.06 μM against wild-type CK1δ, 1.02 μM against the CK1δ kinase domain, and 7.07 μM against CK1ε; it shows enhanced inhibitory activity against the M82F CK1δ mutant ( IC 50 = 0.14 μM). IWP-4 is applicable to research related to cancer , Alzheimer's disease (AD), and heart failure.

Application

Products | Products > GMP Small Molecules | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Heart Disease | Products > Disease Areas > Alzheimer's Disease | Products > Disease Areas > Heart Failure | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Neurodegenerative Disease | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Neurological Disease | Products > Research Areas > Cardiovascular Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Wnt | Products > Signaling Pathways > Casein Kinase

Product Information

• Catalog No.: HY-12879G
• CAS No.: 686772-17-8
• Molecular Formula: C23H20N4O3S3
• Molecular Weight: 496.62
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source