Go 6983 GMP is Go 6983 ( HY-13689 ) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Go 6983 is a dual inhibitor targeting Suv39h1/2 (KMT1A/KMT1B) and PKC , as well as a transcriptional activator capable of inducing DNA hypomethylation. Go 6983 stimulates the transcription of Prdm14 by reducing Suv39h1/2 protein levels, decreasing histone modifications in the Prdm14 promoter region, and increasing the recruitment of RNA polymerase II. Go 6983 induces genome-wide DNA hypomethylation by inhibiting de novo methyltransferase expression and increasing Tet1/Tet2 levels, thereby promoting self-renewal and pluripotency maintenance of stem cells. Meanwhile, Go 6983 can block PKC-mediated signaling pathways to reduce the expression of EMT -related genes and eliminate the upregulation of antioxidant genes downstream of NRF2 . Go 6983 is mainly used in mechanism studies related to myocardial ischemia/reperfusion injury.
Products | Products > GMP Small Molecules | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Oxidative Stress and Inflammation | Products > Disease Areas > Nervous System Injury | Products > Disease Areas > Ischemia-Reperfusion Injury | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > PKC | Products > Signaling Pathways > Histone Methyltransferase | Products > Signaling Pathways > DNA Methyltransferase | Products > Signaling Pathways > DNA/RNA Synthesis
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