SU11657

Overview

SU11657 (N,N-Dimethyl sunitinib) is an orally active multi-targeted tyrosine kinase inhibitor with IC 50 values of 0.04 μM ( c-Kit ), 0.005 μM ( PDGFR ), 0.013 μM ( VEGFR1 ), 0.017 μM ( VEGFR2 ) and 50 nM ( FLT3 ), respectively. SU11657 exhibits anti-angiogenic activity. SU11657 delays leukemia progression, synergizes with ATRA ( HY-14649 ) to reduce leukemia burden, and inhibits symptoms and tissue damage associated with rheumatoid arthritis. SU11657 can be used in research related to FLT3-mutated acute promyelocytic leukemia, rheumatoid arthritis, neuroblastoma, and benign/atypical meningioma.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Arthritis | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Neuroblastoma | Products > Disease Areas > CNS Neoplasm | Products > Disease Areas > Rheumatoid Arthritis | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > c-Kit | Products > Signaling Pathways > PDGFR | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > FLT3

Product Information

• Catalog No.: HY-138032
• CAS No.: 326914-17-4
• Molecular Formula: C20H23FN4O2
• Molecular Weight: 370.43
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source