NEO212

Overview

NEO212 is an orally active, blood-brain barrier permeable conjugate of Temozolomide (TMZ) ( HY-17364 ) and Perillyl Alcohol (POH) (HY-N7000), with potent anticancer activity. NEO212 overcomes classical TMZ resistance and DNA alkylation by depleting MGMT . By inhibiting the FAK/Src signaling pathway, NEO212 reduces the production of MMP2 and MMP9 , induces mesenchymal-epithelial transition, and inhibits the migration, invasion and tumor progression of glioma stem cells. NEO212 disrupts autophagy flux to enhance mitochondrial apoptosis ; it induces differentiation of acute myeloid leukemia (AML) cells into macrophages and proliferation arrest.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Ovarian Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Glioma | Products > Disease Areas > Acute Myeloid Leukemia | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Autophagy | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Src | Products > Signaling Pathways > MMP | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > FAK

Product Information

• Catalog No.: HY-138195
• CAS No.: 1361198-79-9
• Molecular Formula: C17H20N6O4
• Molecular Weight: 372.39
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source