BET-IN-18

Overview

BET-IN-18 (Compound 3) is a pan- BET bromodomain small-molecule inhibitor, with K i values of 0.69 μM and 0.37 μM, and K d values of 1.6 μM and 8.4 μM against BrdT (1) and Brd4 (1) bromodomains, respectively. BET-IN-18 potently and competitively inhibits the binding of the known BET inhibitor (+)-JQ1 ( HY-13030 ) to Brd4 (1) and BrdT (1), with IC 50 values of 1.0 μM and 2.3 μM, respectively. BET-IN-18 also competitively inhibits the binding of acetylated histone substrates to Brd4 (1) ( IC 50 = 0.90 μM). BET-IN-18 can be used in the research of multiple myeloma.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Multiple Myeloma | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > Epigenetic Reader Domain

Product Information

• Catalog No.: HY-155891
• CAS No.: 874594-37-3
• Molecular Formula: C18H17N3O4
• Molecular Weight: 339.35
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source