SPR519 is a selective, orally active dual PI3Kα / mTOR kinase inhibitor, with an IC 50 of 0.03 μM against PI3Kα and an IC 50 of 0.01 μM against mTOR . SPR519 exhibits anticancer effects in ovarian cancer and colon cancer xenograft models. SPR519 can be used for the research of solid tumors (ovarian cancer , colon cancer ).
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