(S)-HTS-3 is a Lysophosphatidylcholine acyltransferase 3 ( LPCAT3 / MBOAT5 ) inhibitor with a human IC 50 of 4.1 μM. (S)-HTS-3 inhibits the acyltransferase activity of LPCAT3 . (S)-HTS-3 modestly reduces incorporation of deuterated arachidonic acid into C20:4 phosphatidylserine in myeloid leukemia cells.
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