Ravoxertinib GMP is Ravoxertinib ( HY-15947 ) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Ravoxertinib (GDC-0994) is an orally active ERK1/2 inhibitor. Ravoxertinib inhibits the ERK1/2 MAPK signaling pathway and reduces the expression levels of c-Myc , HK2 and LDHA . Ravoxertinib decreases mammosphere formation, and exerts additive and/or superadditive cytotoxicity when combined with Ipatasertib ( HY-15186 ) in 3D tumor sphere models. Ravoxertinib can be used in research related to various cancers including breast cancer , melanoma, head and neck cancer , non-small cell lung cancer , ovarian cancer and Merkel cell carcinoma.
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