TRK-IN-28

Overview

TRK-IN-28 (compound 30f) is a TRK inhibitor with the IC 50 values of 0.55 nM, 25.1 nM and 5.4 nM against TRK WT , TRK G595R and TRK G667C , respectively. TRK-IN-2 shows antiproliferative activity with IC 50 values of 9.5, 3.7, 205.0 and 48.3 nM against Ba/F3-ETV6-TRKA WT , Ba/F3-ETV6-TRKB WT , Ba/F3-LMNA-TRK G595R and Ba/F3-LMNA-TRKA G667C , respectively.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Trk Receptor

Product Information

• Catalog No.: HY-163366
• CAS No.: 2991504-43-7
• Molecular Formula: C27H25F2N7
• Molecular Weight: 485.53
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source