SGX393

Overview

SGX393 (SGX70393) is a Bcr-Abl kinase inhibitor. SGX393 binds to the active conformation of the kinase domains of both wild-type and T315I mutant Bcr-Abl , thereby inhibiting kinase activity. SGX393 exhibits antiproliferative effects in cells expressing wild-type or T315I mutant Bcr-Abl , and suppresses T315I-driven tumor growth. SGX393 can be used for the research of chronic myeloid leukemia.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Chronic Myelogenous Leukemia | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer | Products > Signaling Pathways > Bcr-Abl

Product Information

• Catalog No.: HY-165532
• CAS No.: 1030610-86-6
• Molecular Formula: C21H22N6O
• Molecular Weight: 374.45
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source