(Rac)-Mefloquine ((Rac)-Mefloquin) is an orally active NF-κB inhibitor. (Rac)-Mefloquine inhibits the NF-κB and IKK signaling pathways, suppresses NF-κB -Luc luciferase activity, blocks the activation of p65 and IκBα , and reduces the expression of downstream target genes of NF-κB . (Rac)-Mefloquine activates apoptosis -related factors and induces apoptosis in tumor cells. (Rac)-Mefloquine functions as a tumor cell inhibitor. (Rac)-Mefloquine can be used for the research of colorectal cancer .
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