PIM-IN-4 is a Pim kinase inhibitor with K i values of 2, 3, and 0.5 nM against Pim-1, 2, 3 , respectively. PIM-IN-4 blocks the phosphorylation of the pro-apoptotic protein Bad . PIM-IN-4 inhibits the growth of leukemia cells. PIM-IN-4 is applicable for leukemia-related research.
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