Telomeric G4s ligand 2

Overview

Telomeric G4s ligand 2 is an orally active, selective ligand of telomeric G-quadruplex (G4) , with an IC 50 of 0.4 μM. Telomeric G4s ligand 2 binds to dimeric telomeric G4, inhibits the activities of DHX36 and BLM helicases. Telomeric G4s ligand 2 activates cGAS-STING and TERRA-ZBP1 pathways, inducing autophagy and G2/M cell cycle arrest, and exhibits antiproliferative effects across cancer cell lines. Telomeric G4s ligand 2 can be used for the study of colorectal cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Autophagy | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > G-quadruplex | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > Cyclic GMP-AMP Synthase | Products > Signaling Pathways > STING | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-181850
• CAS No.: 3094716-52-3
• Molecular Formula: C25H32N6O
• Molecular Weight: 432.56
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source