PARP1/c-Met-IN-3

Overview

PARP1/c-Met-IN-3 (Compound L19) is a selective c-Met and PARP1 inhibitor, with an IC 50 of 5.4 nM against c-Met and an IC 50 of 3.7 nM against PARP1 . PARP1/c-Met-IN-3 inhibits PARP2 enzymatic activity with an IC 50 of 4.52 nM, and shows no specificity for PARP1 and PARP2 . PARP1/c-Met-IN-3 induces cell cycle arrest and apoptosis . PARP1/c-Met-IN-3 exhibits anti-tumor activity against triple-negative breast cancer .

Application

Products | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Triple-Negative Breast Cancer | Products > Disease Areas > Cancer | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > c-Met/HGFR | Products > Signaling Pathways > PARP | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-181928
• CAS No.: 3123529-62-1
• Molecular Formula: C38H28FN9O2
• Molecular Weight: 661.69
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source