ClpP activator-2

Overview

ClpP activator-2 (Compound GU18) is a ClpP activator with a K d of 5.01 μM for HsClpP. ClpP activator-2 enhances the proteolytic activity of HsClpP and promotes the degradation of α-casein by HsClpP, with an EC 50 of 1.09 μM. ClpP activator-2 induces the accumulation of mitochondrial reactive oxygen species ( ROS ), leading to damage to mitochondrial structure and function. ClpP activator-2 exhibits significant in vivo anti-multiple myeloma activity.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Multiple Myeloma | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > ClpP | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Mitochondrial Metabolism

Product Information

• Catalog No.: HY-181934
• CAS No.: 3125957-10-7
• Molecular Formula: C23H21F5N4O
• Molecular Weight: 464.43
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source