MPAM-15 is a blood-brain barrier-penetrant pan-orthosteric allosteric modulator ( PAM ) of opioid receptors, with ≥16-fold selectivity for μOR over δOR and κOR . MPAM-15 acts as an anti-nociceptive potentiator and analgesic, and its activity is observed in mouse models via both intracerebroventricular and intraperitoneal administration. MPAM-15 is applicable for pain-related research.
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