KB528

Overview

KB528 is a p300/CBP histone acetyltransferase (KAT) inhibitor with low nM IC 50 values against human p300 and CBP , and exhibits selectivity over other KAT family members. KB528 modulates the IRF4 transcriptional network, downregulates the expression of IRF4 , MYC , CAV2 and IGLL5 , and reduces the protein level of IKZF3 . KB528 potently induces apoptosis in multiple myeloma cells. KB528 is applicable to research related to multiple myeloma.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Multiple Myeloma | Products > Disease Areas > Cancer | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Epigenetic Reader Domain | Products > Signaling Pathways > Histone Acetyltransferase | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > IKZF Family

Product Information

• Catalog No.: HY-181957
• CAS No.: 3082090-83-0
• Molecular Formula: C28H28N6O
• Molecular Weight: 464.56
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source