SCH 79687

Overview

SCH 79687 is an orally active histamine H3 receptor antagonist, with a K i of 1.9 nM in rats and 13 nM in guinea pigs. SCH 79687 acts as a competitive antagonist against (R)-α-methylhistamine. SCH 79687 attenuates the inhibitory effect of (R)-α-methylhistamine-induced sympathetic hypertensive responses in guinea pigs. When used in combination with H1 antagonists, SCH 79687 inhibits Compound 48/80 ( HY-115768 )-induced nasal congestion in cats. SCH 79687 can be used for the research of allergic rhinitis.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Allergy | Products > Disease Areas > Allergic Rhinitis | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Histamine Receptor

Product Information

• Catalog No.: HY-182296
• CAS No.: 224585-45-9
• Molecular Formula: C18H16Cl2N4O
• Molecular Weight: 375.25
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source