TrxR2-IN-1

Overview

TrxR2-IN-1 is a thioredoxin reductase 2 ( TrxR2 ) inhibitor with an IC 50 value of 0.83 μM. TrxR2-IN-1 accumulates in mitochondria, impairs mitochondrial function and membrane potential, increases reactive oxygen species ( ROS ) levels, activates ASK1 -mediated caspase-dependent apoptosis ( apoptosis ), induces G2/M cell cycle arrest, and inhibits cancer cell migration. TrxR2-IN-1 can be used in the research of hepatocellular carcinoma.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Hepatitis B Virus Related Hepatocellular Carcinoma | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > TrxR | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Caspase

Product Information

• Catalog No.: HY-182324
• CAS No.: 3085154-16-8
• Molecular Formula: C50H60BrO3P
• Molecular Weight: 819.89
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source