TMLZ-G46 is an orally active ZNF207 inhibitor with blood-brain barrier penetration ability, with a K d value of 68 nM. TMLZ-G46 inhibits cancer cell proliferation, stemness, migration and invasion, induces G0/G1 cell cycle arrest and apoptosis , and suppresses colony formation. TMLZ-G46 can be used in glioma research.
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