5-HT2C agonist-13 is an orally active, selective and brain-penetrant 5-HT 2C receptor agonist with human 5-HT 2C receptor EC 50 of 16 nM, K i of 20 nM. 5-HT2C agonist-13 functionally activates 5-HT 2C receptors, reduces food intake, reduces body weight gain, and exhibits effects reversible by a selective 5-HT 2C antagonist. 5-HT2C agonist-13 can be used for the research of obesity.
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