SLB1122168 free base is a Spinster Homolog 2 ( Spns2 ) inhibitor. SLB1122168 free base inhibits Spns2-mediated sphingosine-1-phosphate ( S1P ) release with an IC 50 of 94 nM. SLB1122168 free base induces lymphopenia in circulating lymphocytes in mice and rats.
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