GQ127

Overview

GQ127 is an orally active Gαq/11 inhibitor with an IC 50 of 22.6 μM. GQ127 binds directly to Gαq/11 protein and inhibits its activity. GQ127 induces Apoptosis , suppresses viability, migration and invasion of uveal melanoma cells. GQ127 increases the phosphorylation level of YAP and decreases the phosphorylation level of ERK . GQ127 inhibits the growth of uveal melanoma xenografts in mouse models. GQ127 can be used for research related to uveal melanoma.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > YAP | Products > Signaling Pathways > ERK

Product Information

• Catalog No.: HY-182405
• CAS No.: 2625582-70-7
• Molecular Formula: C25H36N4O
• Molecular Weight: 408.58
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source