LEM-06

Overview

LEM-06 is an NSD2 inhibitor with a human IC 50 of 890 μM and 0.8 mM. LEM-06 binds to the histone-tail binding groove of NSD2 -SET, inhibiting NSD2 -mediated H3K36 histone methyltransferase activity and H3K36 mono-methylation. LEM-06 serves as a hit molecule for further optimization or derivation to explore NSD2 biology. LEM-06 can be used for the research of multiple myeloma.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Multiple Myeloma | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > Histone Methyltransferase

Product Information

• Catalog No.: HY-182486
• CAS No.: 1212675-57-4
• Molecular Formula: C29H38N4O3
• Molecular Weight: 490.64
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source