GP515

Overview

GP515 is a potent and selective adenosine kinase inhibitor with a human IC 50 of 4 nM. GP515 exerts tissue protective effects, produces long-lasting hepatic microcirculation effects after hemorrhagic shock, and induces dose- and time-related VEGF mRNA and protein expression in normoxic rat myocardial myoblasts, with additive VEGF increases during mild hypoxia and no effect during severe hypoxia. GP515 suppresses IFNγ synthesis and CD69 expression in DSS-induced colitis. GP515 also shows a dose-dependent suppression of TNF-α production with an IC 50 of 80 μM and can be reversed in the presence of the cAMP antagonist (Rp)-cAMPS. Combinations of GP515 with either adenosine or rolipram led to an additive inhibition of TNF-α synthesis. GP515 can be used for the research of hemorrhagic shock.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Others | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Inflammatory Bowel Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Others | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Adenosine Kinase

Product Information

• Catalog No.: HY-182503
• CAS No.: 144928-48-3
• Molecular Formula: C10H13BrN6O3
• Molecular Weight: 345.15
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source