Indoluidin D is a selective dihydroorotate dehydrogenase ( DHODH ) inhibitor with a human DHODH IC 50 of 210 nM. Indoluidin D selectively inhibits human DHODH activity, with induced effects rescuable by orotic acid. Indoluidin D promotes myeloid differentiation and inhibits cancer cell proliferation. Indoluidin D can be used for the research of acute promyelocytic leukemia.
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