ST45177901 is a CC chemokine receptor 4 ( CCR4 ) antagonist. The combination of ST45177901 and Sorafenib ( HY-10201 ) effectively inhibits the chemotaxis of Treg cells via the CCL22/CCL17-CCR4 signaling pathway, thereby significantly suppressing the growth and metastasis of tumor cells. ST45177901 is applicable to liver cancer research.
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