FR 111142

Overview

FR 111142 is an angiogenesis inhibitor ( IC 50 = 18.4 μM) and has anti-inflammatory activity ( IC 50 = 20.6 μM). FR 111142 inhibits capillary-like tube formation as well as nitric oxide production in LPS ( HY-D1056 )-activated murine macrophages. FR 111142 enhances catabolism of low-density lipoprotein (LDL). FR 111142 does not induce significant cytotoxicity in human endothelial progenitor cells, nor affect cell viability of murine macrophages. FR 111142 can be used for the research of cancer , inflammatory diseases.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > VEGFR

Product Information

• Catalog No.: HY-182569
• CAS No.: 132340-44-4
• Molecular Formula: C22H34O7
• Molecular Weight: 410.50
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source