WB214

Overview

WB214 is an MDM2 and GSPT1 degrader with human MDM2 K i >10 μM. WB214 induces a neo-interaction between MDM2 and the cereblon E3 ligase complex, triggering MDM2 ubiquitination, proteasomal degradation, and bystander p53 degradation, and does not bind MDM2’s p53 binding region. WB214 induces GSPT1 degradation, and exhibits anti-proliferative activity in leukemia cells. WB214 can be used for the research of leukemia.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > MDM-2/p53

Product Information

• Catalog No.: HY-182623
• CAS No.: 2640723-72-2
• Molecular Formula: C44H43ClF3N5O7
• Molecular Weight: 846.29
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source