MT16-001

Overview

MT16-001 is a cell-permeable UCHL1 inhibitor with an IC 50 value of 580 nM. MT16-001 also exhibits considerable inhibitory activity against USP30 , and shows selectivity for other UCH family deubiquitinases (DUBs) as well as the broader proteome. MT16-001 binds covalently to the cysteine residue at the active site of UCHL1 , and forms covalent interactions with ALDH2 , ALDH9A1 and GATD3A in intact cells. Meanwhile, as a cytotoxic agent, it displays a steep dose-response curve in human embryonic kidney cells. MT16-001 can be used for research on various cancers, liver fibrosis and pulmonary fibrosis.

Application

Products | Products > Disease Areas > Liver Disease | Products > Disease Areas > Lung Fibrosis | Products > Disease Areas > Hepatic Fibrosis | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Pulmonary Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Deubiquitinase | Products > Signaling Pathways > Aldehyde Dehydrogenase (ALDH)

Product Information

• Catalog No.: HY-182636
• CAS No.: 1895049-73-6
• Molecular Formula: C15H14N4OS
• Molecular Weight: 298.36
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source