JWX-A0108

Overview

JWX-A0108 is a selective human α7 nAChR positive allosteric modulator with an EC 50 of 4.35 μM. JWX-A0108 potentiates α7 nAChR currents only in the presence of acetylcholine, with no direct activating effect or alteration of desensitization. JWX-A0108 enhances hippocampal GABAergic synaptic transmission by increasing spontaneous inhibitory postsynaptic currents. JWX-A0108 reduces the brain expression levels of IL-1β , TNF-α , and IL-6 by blocking the NF-κB signaling pathway, and reduces microglial activation by downregulating Iba1 . JWX-A0108 effectively improves cognitive deficits, neuroinflammation, and hippocampal neuronal damage in mouse models of schizophrenia and Alzheimer's disease. JWX-A0108 can be used for research related to schizophrenia and Alzheimer's disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Schizophrenia | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > NF-κB | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > nAChR | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > TNF Receptor

Product Information

• Catalog No.: HY-182707
• CAS No.: 2055045-42-4
• Molecular Formula: C19H14ClFN4OS
• Molecular Weight: 400.86
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source