N 0840 is a neutral antagonist of adenosine A 1 receptor ( A 1 AR ), with a K i value of 279 nM in rats and 1185 nM in humans. N 0840 modulates adenosine A 1 receptor to increase forskolin-induced cyclic 3′,5′-adenosine monophosphate production, with a GTP shift value close to 1. N 0840 can be used in studies of neuroprotection, cardiovascular/renal function [1] .
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