Pipinib

Overview

Pipinib is an ATP-competitive and selective phosphatidylinositol 4-kinase IIIb ( PI4KB ) inhibitor with an IC 50 of 2.2 μM. Pipinib reduces intracellular PI4P levels. Pipinib inhibits GLI-mediated transcription, the expression of Hedgehog target genes, and blocks the trafficking of Smoothened to cilia. Pipinib can be used in the research of basal cell carcinoma and medulloblastoma.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Signaling Pathways > PI4K | Products > Signaling Pathways > Hedgehog

Product Information

• Catalog No.: HY-182721
• CAS No.: 2380013-55-6
• Molecular Formula: C17H18N4O2S
• Molecular Weight: 342.42
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source