YM-344484

Overview

YM-344484 is an orally active dual antagonist of chemokine CCR3 receptor and histamine histamine H1 receptor . YM-344484 inhibits ligand-induced Ca 2+ influx, chemotaxis of CCR3 -expressing cells, histamine-induced Ca 2+ influx, increased vascular permeability and eosinophil accumulation. YM-344484 suppresses vascular permeability and inhibits eosinophil infiltration in a mouse asthma model. YM-344484 can be used in research related to asthma, allergic rhinitis and atopic dermatitis.

Application

Products | Products > Disease Areas > Allergy | Products > Disease Areas > Skin Inflammation | Products > Disease Areas > Allergic Asthma | Products > Disease Areas > Allergic Rhinitis | Products > Disease Areas > Atopic Dermatitis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > CCR | Products > Signaling Pathways > Histamine Receptor | Products > Signaling Pathways > Calcium Channel

Product Information

• Catalog No.: HY-182736
• CAS No.: 671205-14-4
• Molecular Formula: C28H30FN5O2
• Molecular Weight: 487.57
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source