Tubulin-IN-66

Overview

Tubulin-IN-66 is a tubulin ( tubulin ) and P-gp inhibitor with antiproliferative activity against cancer cells. Tubulin-IN-66 covalently binds to the Colchicine ( HY-16569 )-binding site at Cys239 of the β-tubulin subunit, inhibits tubulin polymerization and disrupts the microtubule network. Tubulin-IN-66 inhibits P-gp function to overcome multidrug resistance. Tubulin-IN-66 arrests the cell cycle at the G2/M phase and induces apoptosis ( apoptosis ). Tubulin-IN-66 inhibits colony formation and migration of cancer cells. Tubulin-IN-66 can be used in the research of tumors such as breast cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Microtubule/Tubulin | Products > Signaling Pathways > P-glycoprotein | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > CDK

Product Information

• Catalog No.: HY-182753
• CAS No.: 3110538-32-1
• Molecular Formula: C22H24N2O6
• Molecular Weight: 412.44
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source