FLC-8

Overview

FLC-8 is an orally active FLT3 inhibitor with IC 50 values of 10.2 nM, 11.6 nM and 24.10 nM against human FLT3-WT , FLT3-G697R and FLT3-N676D , respectively. FLC-8 inhibits FLT3 autophosphorylation and downstream STAT5 , AKT and ERK signaling pathways, and induces apoptosis in acute myeloid leukemia (AML) cells. FLC-8 exhibits potent antitumor activity in the MV4-11 xenograft model. FLC-8 can be used for the research of acute myeloid leukemia.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Acute Myeloid Leukemia | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > FLT3 | Products > Signaling Pathways > STAT | Products > Signaling Pathways > Akt | Products > Signaling Pathways > ERK | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > PARP | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-182937
• CAS No.: 3100242-36-9
• Molecular Formula: C24H19F3N6O3
• Molecular Weight: 496.44
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source