DC551040

Overview

DC551040 is an orally active and selective lysine demethylase 1 ( LSD1 ) inhibitor with a human IC 50 of 2.14 nM. DC551040 binds to LSD1 via π-π stacking with Trp552 , polar interactions with Phe538 , and covalent adduct formation with FAD , and disrupts the LSD1 - GFI1B - CoREST complex. DC551040 induces H3K4me2 accumulation, apoptosis , and cell differentiation, activates STAT5 , NF-κB , AKT , and IL6 - STAT3 pathways, and upregulates IL6 expression. DC551040 can be used for the research of acute myeloid leukemia.

Application

Products | Products > Disease Areas > Acute Myeloid Leukemia | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Histone Demethylase | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-183105
• CAS No.: 2133291-32-2
• Molecular Formula: C22H32FN3O2
• Molecular Weight: 389.51
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source