Zolertine is an α-adrenergic receptor antagonist, with a pK i of 6.35 for rabbit α 1 A-adrenergic receptor and a pK i of 6.81 for rat α 1 B-adrenergic receptor. Zolertine competitively blocks α 1 D-adrenergic receptor-mediated vasoconstriction and α 1 A-adrenergic receptor-mediated vasoconstriction in arteries. Zolertine can be used in the research of hypertension.
Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Hypertension | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Adrenergic Receptor
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