ATI-1

Overview

ATI-1 is an autophagy initiation inhibitor. ATI-1 targets valosin-containing protein ( VCP/p97 , disrupts its interaction with UFL1 , impairs UFMylation homeostasis associated with VCP, promotes polyubiquitination and degradation of Beclin1 , and blocks the formation of early autophagosomes. ATI-1 induces synergistic death of autophagy-dependent malignant tumor cells under nutrient deprivation conditions, accompanied by decreased mitochondrial membrane potential, reduced ROS levels and lysosomal stress. ATI-1 exhibits anti-tumor efficacy in a pancreatic adenocarcinoma xenograft mouse model. ATI-1 can be used for the research of pancreatic adenocarcinoma and lung cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > p97 | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Beclin1 | Products > Signaling Pathways > Reactive Oxygen Species (ROS)

Product Information

• Catalog No.: HY-183257
• CAS No.: 1242983-93-2
• Molecular Formula: C16H14F2N2O2S3
• Molecular Weight: 400.49
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source