FTO-IN-17

Overview

FTO-IN-17 is an orally active and brain-penetrant FTO (m 6 A RNA demethylase) inhibitor with an IC 50 of 1.1 μM. FTO-IN-17 stably binds the FTO catalytic pocket. FTO-IN-17 protects against Aβ1-42-induced toxicity while increasing global m 6 A levels and dampening pro-inflammatory gene ( CXCL10 , TNF-α ) expression. FTO-IN-17 ameliorates anxiety-like behavior and rescues hippocampal-dependent spatial, recognition memory and neuroinflammation in Alzheimer's disease mice models.

Application

Products | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Fat Mass and Obesity-associated Protein (FTO) | Products > Signaling Pathways > CXCR | Products > Signaling Pathways > TNF Receptor

Product Information

• Catalog No.: HY-183325
• CAS No.: 1434867-98-7
• Molecular Formula: C20H23FN4O2
• Molecular Weight: 370.42
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source