TDP1-IN-5

Overview

TDP1-IN-5 is a tyrosyl-DNA phosphodiesterase 1 ( TDP1 ) inhibitor with an IC 50 of 2.2 μM. By targeting TDP1 both intracellularly and extracellularly, TDP1-IN-5 inhibits the NHEJ repair pathway, arrests the cell cycle at the G2/M phase, upregulates PIG3 to enhance ROS , and ultimately significantly potentiates ionizing radiation (IR)-induced DNA damage and apoptosis . TDP1-IN-5 can be used in the research of colorectal cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Phosphodiesterase (PDE) | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-183334
• CAS No.: 3115524-78-9
• Molecular Formula: C34H45N5O5
• Molecular Weight: 603.75
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source