BuChE-IN-23

Overview

BuChE-IN-23 is an orally active, blood-brain barrier permeable butyrylcholinesterase ( eqBuChE ) inhibitor with an IC 50 of 15.59 μM and a K i of 29.33 μM. BuChE-IN-23 exhibits an IC 50 of 38.65 μM against hBuChE and shows selectivity for butyrylcholinesterase over acetylcholinesterase. BuChE-IN-23 inhibits LPS ( HY-D1056 )-induced nitric oxide production, attenuates hippocampal glial cell activation and neuroinflammation, suppresses the TLR4 / p38 MAPK signaling pathway, and regulates the IL-1β/C3 -mediated microglia-astrocyte inflammatory axis. BuChE-IN-23 can be used for the research of Alzheimer's disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Cholinesterase (ChE) | Products > Signaling Pathways > Toll-like Receptor (TLR) | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > Complement System

Product Information

• Catalog No.: HY-183352
• CAS No.: 3067571-93-8
• Molecular Formula: C25H25NO6
• Molecular Weight: 435.47
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source