USP1-IN-18

Overview

USP1-IN-18 is an orally active USP1 inhibitor with a human IC 50 of 17.0 nM. USP1-IN-18 inhibits USP1-UAF1 deubiquitinase activity and drives ubiquitinated PCNA accumulation. USP1-IN-18 induces DNA damage, replication stress, and G2-M phase cell cycle arrest. USP1-IN-18 can be used for the research of triple-negative breast cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Triple-Negative Breast Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Deubiquitinase | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-183581
• CAS No.: 3064481-29-1
• Molecular Formula: C26H22F3N7O2
• Molecular Weight: 521.49
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source