HIF-2α-IN-18

Overview

HIF-2α-IN-18 is a selective HIF-2α inhibitor with a human IC 50 of 8.1 nM. HIF-2α-IN-18 binds to the HIF-2α PAS-B domain, induces conformational perturbations at the HIF-2α / ARNT dimerization interface, destabilizes the HIF-2α/ARNT heterodimer, and blocks HIF-2α-mediated transcriptional activity. HIF-2α-IN-18 inhibits hypoxia-induced expression of HIF-2α target genes EPO and SERPINE1 , without inhibiting HIF-1α target genes PGK1 and PDK1 . HIF-2α-IN-18 can be used for the research of clear cell renal cell carcinoma, hepatocellular carcinoma [1] .

Application

Products | Products > Disease Areas > Renal Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > HIF/HIF Prolyl-Hydroxylase

Product Information

• Catalog No.: HY-183583
• CAS No.: 2709068-47-1
• Molecular Formula: C18H8F7N3
• Molecular Weight: 399.27
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source