AZD4956

Overview

AZD4956 is a potent and selective DNA polymerase theta (POLQ) inhibitor. AZD4956 exhibits an IC 50 value of less than 3 μmol/L against POLQ and 3.4 μmol/L against MMEJ . AZD4956 suppresses the MMEJ pathway and enhances the activity of DNA-damaging agents in HRR -deficient cellular contexts. AZD4956 shows antitumor activity in BRCA1/2-mutated triple-negative breast cancer and prostate cancer models. AZD4956 can be used for the study of homologous recombination-deficient tumors.

Application

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Product Information

• Catalog No.: HY-183630
• CAS No.: 3045469-78-8
• Molecular Formula: C28H25Cl2N5O4
• Molecular Weight: 566.44
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source